Presently, whether the miR-100 could play a role in the pathogenesis of ACC via Plk1 or CXCR7 downstream pathways has not yet been clarified; on the contrary, in vitro studies have pointed out a direct action of miR-100 on the expression of IGF1R and mammalian target of rapamycin (mTOR) [51]. The gene discussed is ACKR3; the disease is adrenal cortex carcinoma.