miR-139-5p expressions have been demonstrated to be inversely correlated with the N-Myc downstream-regulated gene (NDRG) family member NDRG4 expressions in ACC, and in ACC cell model inhibition of miR-139-5p or restoration of NDRG4, which effectively suppressed the invasive potential of H295R and SW13 in vitro. Here, NDRG4 is linked to adrenal cortex carcinoma.