STING-associated vasculopathy with infancy onset is a rare IFN-mediated disorder characterized by early vasculitis localized to cheeks, ears, nose and fingers (bearing a high risk of gangrene) and chronic interstitial lung disease, for which there is constitutive activation of the STING protein, a key activator of type I IFN axis [73]. Here, STING1 is linked to gangrene.