Furthermore, the combination of generalized pustular psoriasis, early-onset plaque psoriasis and pityriasis rubra pilaris may be related to sporadic or dominant gain-of-function mutations in the CARD14 gene, highly expressed in keratinocytes: the disease is called CARD14-mediated psoriasis (also known as CAMPS) and is characterized by NFKB increased signaling [63]. Here, CARD14 is linked to familial pityriasis rubra pilaris.