Fireman and co-authors evaluated cytoskeleton proteins by enzyme-linked immunosorbent assay (ELISA) and immunofluorescent methods, revealing that α smooth muscle actin (α-SMA) measured by ELISA was higher in IPF than in sarcoidosis, and that only IPF revealed myofibroblast phenotypes, showing α-SMA immunofluorescence labeling and filaments with associated dense bodies with rough endoplasmic reticulum through electron microscopy [11]. Here, ACTA1 is linked to idiopathic pulmonary fibrosis.