MAPT and Alzheimer disease: It has been previously reported that aberrant intracellular β-Amyloid (iAβ) interacts with several cell organelles, including accumulation commencing in endosomes, mitochondrial localization of iAβ and association of both key AD markers, iAβ and Tau, with endoplasmic reticulum and lysosome, serving as key organelles in the pathogenesis of AD [57,58,59].