Mice lacking Bmp-2 (Osx-Cre;Bmp-2fx/fx, Collα1-Cre;Bmp-2fx/fx, Wnt1-Cre-;Bmp-2) exhibit dentinogenesis imperfecta type II and type III (DGI-II, DGI-III), and dentin dysplasia type II (DD-II) [32,36,37,38,39]. The gene discussed is BMP2; the disease is dentin dysplasia type II.