Many signaling pathways are associated with the development of cancer such as VEGF receptor pathway that activate RAS/RAF/MEK/ERK pathway, and the fibroblast growth factor (FGF) receptor pathway that stimulates multiple pathways, including the PI3K/Akt/mTOR, RAS/RAF/MEK/ERK and act as signal transducer and activator of transcription (STAT) pathways [88,89]. This evidence concerns the gene AKT1 and cancer.