Based on gene expression data in established human cancer cell lines from the Cancer Cell Line Encyclopedia (CCLE) portal (https://portals.broadinstitute.org/ccle/home, accessed on 20 May 2022), expression of AMPK genes correlated with epithelial cell markers (E-cadherin and EPCAM) and inversely with various mesenchymal cell markers (Figure 3A). The gene discussed is PRKAA2; the disease is cancer.