APOE and atherosclerosis: Considering the pro-inflammatory effect of PIEZO1 under DF, two studies have shown that Piezo1 deficiency relieved atherosclerosis in LDL receptor-deficient (LDLR−/−) mice [21], and pharmacological inhibition of Piezo1 by GsMTx-4 administration attenuated plaque formation in ApoE−/− mice [65].