As a critical mechanosensitive ion channel in endothelial cells, PIEZO1 plays diverse roles in endothelial shear stress sensing, nitric oxide (NO) generation, vascular tone, angiogenesis, atherosclerosis, vascular permeability and remodeling, blood pressure regulation, etc [18,19,20,21,22,23,24]. This evidence concerns the gene PIEZO1 and atherosclerosis.