AKT1 and Alzheimer disease: In this work, the autophagy cell signaling was analyzed, and the results show that the phosphorylation status of AKT, ERK, and cytosolic and nuclear p70S6 kinases as well as the expression of LAMP2A and Beclin-1 increase in the D4T-stimulated PBMC of AD patients, indicating that D4T upregulates the pro-autophagic downstream AKT- and MAP-kinase pathways.