NLRP3 and Alzheimer disease: Results obtained by AMNIS FlowSight, when NLRP3 and apoptosis-associated speck-like-protein containing CARD (ASC)-speck formation was investigated showed that in the PBMC of AD patients, D4T prevented the generation of ASC-specks impeding the assembly of NLRP3-inflammasome complexes (Figure 1a,b).