In our recent study, we showed the following effects of the intracellular production of TAGE: reductions in the level of Aβ42 and increases in the levels of total tau and p-tauT181 in culture media, as well as increases in the intracellular levels of total tau, p-tauT181, VEGF, and TGF-β in human neuroblastoma SH-SY5Y cells [39]. The gene discussed is MAPT; the disease is neuroblastoma.