Thus, we determined the frequencies of naïve (n; CD45RO− CCR7+), central memory (CM; CD45RO+ CCR7+), effector memory (EM; CD45RO+ CCR7−), and terminally differentiated effector T-cells (EMRA; CD45RO− CCR7−) [26] (gating strategy see Supplementary Figure S2E) in absence or presence of CLL-EVs. The gene discussed is CCR7; the disease is B-cell chronic lymphocytic leukemia.