Previously, transcriptome-wide mRNA profiling in melanoma cells demonstrated TP-472 not only upregulated pro-apoptotic genes such as BAX, CDKN1A, GADD45A, GAD45B, among others, associated with the p53 pathway, but also downregulated several extracellular matrix proteins, which are required for tumor growth [34]. The gene discussed is GADD45A; the disease is melanoma.