Thus, we comment on AEN, APE1, ARTEMIS (DCLRE1C), EXD2, EXO1, EXOG, FAN1, FEN1, MRE11A, p53, PLD3, PDL4, POLD1, POLE, RAD9A, TREX1, TREX2, and WRN, most of them included in the recently curated list of DNA Damage Repair genes in cancer [35]. Here, FEN1 is linked to cancer.