Thus, we comment on AEN, APE1, ARTEMIS (DCLRE1C), EXD2, EXO1, EXOG, FAN1, FEN1, MRE11A, p53, PLD3, PDL4, POLD1, POLE, RAD9A, TREX1, TREX2, and WRN, most of them included in the recently curated list of DNA Damage Repair genes in cancer [35]. This evidence concerns the gene PLD3 and cancer.