CAFs alter the pancreatic cancer microenvironment by the secretion of growth factors such as C-X-C motif chemokine ligand 1 (CXCL1), CXCL12, C-C motif chemokine ligand 8 (CCL8), stromal cell-derived factor-1 (SDF-1), IL-6, IL-11, VEGF and others [24,25,26]. This evidence concerns the gene CXCL12 and familial pancreatic carcinoma.