LSS and neoplasm: In mouse cells lacking WT-TP53, this tumor suppression is lost and there is more activated SREBP-2 and transcription of genes such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), lanosterol synthase, (LSS), squalene monooxygenase (SQLE) and mevalonate metabolites such as mevalonate 5-phosphate (MVAP), geranylgeranyl pyrophosphate (GGPP), and cholesterol are elevated.