The aim of the present study was to use a mouse-based RP model to explore if CDK1 may have a place in degenerating RP photoreceptors, where we focused on the cyclic GMP (cGMP)-protein kinase G (PKG) system, which has been proven to be at least a partial driver of the disease [4]. The gene discussed is PRKG1; the disease is retinitis pigmentosa 1.