Using patient-derived iPSCs that were mutated in WWOX, a gene encoding the WW domain-containing oxidoreductase that was associated with a severe infantile epileptic encephalopathy, Steinberg et al. generated cerebral organoids aged between 10 and 24 weeks and identified impaired expression of the cortical markers TBR1, CTIP2, SATB2, and layering defects that progressively worsened at week 24 [64]. Here, WWOX is linked to infantile epileptic encephalopathy.