SLC3A2 and neoplasm: In this context, Wang et al. reported that CD8+ T cells activated by preceding immunotherapy used interferon-gamma (IFNγ) to downregulate SLC3A2 (another subunit of xc−) and SLC7A11 in the tumor microenvironment, thereby reducing intracellular cystine levels and priming tumor cells towards ferroptosis [33].