In mice, tau protein caused pro-ferroptotic iron accumulation during stroke, and Tau-knockout mice and wild-type mice treated with Lip-1 at reperfusion or 6 h post-reperfusion exhibited significantly better neurological outcomes than vehicle-treated mice, albeit the protective effect of Lip-1 was smaller in the 6 h post-reperfusion group [40]. This evidence concerns the gene MAPT and stroke disorder.