NOX4 and hypertensive heart disease: A few pre-clinical studies have indicated ferroptotic involvement in this entity: knockout of the pro-ferroptotic NADPH oxidase 4 (Nox4) decreased transverse aortic constriction (TAC)-induced left ventricular remodeling in a mouse model simulating hypertensive heart disease [47], and the pharmacological inhibition of ferroptosis through puerarin prevented TAC-induced reduction of the left ventricular ejection fraction [46].