Additionally, it was established that circ-PITX1 induced cancer in GBM through targeting the miR-584-5p/KPNB1 axis, implying that circ-PITX1/miR-584-5p/KPNB1 could be used as a diagnostic marker for GBM patients [84] (Figure 3 and Table 2). This evidence concerns the gene PITX1 and cancer.