The Wnt/-catenin signaling pathway and associated genes such as PRR11, Cyclin A, p-CDK2, VEGFR-1/2, p-VEGFR-1/2, and EGFR were used to arrest cell cycle progression in human glioma U87MG and U251 cells at the S/G2/M phase. This evidence concerns the gene FLT1 and glioma.