Circ-SHKBP1 regulated the angiogenesis of GECs via the miR-544a/FOXP1 and miR-379/FOXP2 pathways, and these findings suggest that circ-SHKBP1 may be a useful target and method for combination therapy of gliomas [91] (Figure 3 and Table 2). The gene discussed is SHKBP1; the disease is central nervous system cancer.