Mutations induce the constitutive activation of the NLRP3 inflammasome and trigger sterile inflammatory diseases, including familial cold autoinflammatory syndrome (FCAS) [182], Muckle–Wells syndrome (MWS) [182], and neonatal-onset multi-systemic inflammatory diseases/chronic infantile neurological cutaneous articular syndrome (NOMID/CINCA) [183]. This evidence concerns the gene NLRP3 and familial cold autoinflammatory syndrome.