NLRP3 and Alzheimer disease: Thus, the NLRP3 inflammasome has been implicated in central nervous system (CNS) diseases, such as multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) [185,186], metabolic diseases including non-alcoholic fatty liver disease (NAFLD), gout, type 2 diabetes, and obesity-induced insulin resistance [187], cardiovascular diseases (CVDs) [17,188], and rheumatoid arthritis (RA) [189] (Figure 4).