Indeed, in our recent analysis of KLK6 in TCGA and Gene Expression Omnibus databases we observed that high KLK6 expression in colonic tumors correlated to mutations in other genes such as Titin (TTN), APC, K-RAS, and MUC16 (CA-125) [25], which are found to be overexpressed or frequently mutated in colon cancer [29]. Here, APC is linked to malignant colon neoplasm.