Figure 2 proposes that in terms of its function in AD, the tau protein is going to be a positive feedback cycle. In addition, more inflammation can also trigger the kinases, that is, inflammation independent of these neurofibrillary tangles [5]. There are also literature reports that indicate, other processes, such as acylation and glycosylation, causes tau malfunction [8,9,10,11]. Here, MAPT is linked to Alzheimer disease.