After SFN-induced AMPKα2 activation, AMPKα2 triggers Akt/GSK-3β phosphorylation and, as a consequence, prevents Fyn from entering the nucleus to output Nrf2, which leads to an increase in nuclear Nrf2 accumulation, thus weakening oxidative stress in type 2 diabetes [60]. This evidence concerns the gene PRKAA2 and type 2 diabetes mellitus.