Interestingly, whilst mutations in the PDE6 subunits cause relatively milder forms of inherited retinal degeneration, mutations in the reported co-chaperone for PDE6, the photoreceptor-specific aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), cause Leber congenital amaurosis (LCA), a severe early onset and rapidly progressive disease leading to photoreceptor degeneration and the loss of vision within the first few years of life [61]. This evidence concerns the gene AIPL1 and Leber congenital amaurosis.