An in-depth understanding of the mechanisms underlying the specific recruitment of PDE6 and GRK1 to Hsp90 is crucial to understand the biogenesis of these important phototransduction proteins, not only in the healthy retina but also in retinal diseases associated with these Hsp90 clients, and the review will henceforth focus on mechanistic and structural insights into PDE6 and GRK1 as Hsp90 client proteins. The gene discussed is HSP90AA1; the disease is Abnormal retinal morphology.