Due to its Ca2+ permeability (PCa/PNa ≈ 7 in HEK293 cells transiently transfected with wild type TRPV4, [2]), activation of TRPV4 induces an increase in cytosolic Ca2+ concentration ([Ca2+]c) which plays a key role in fundamental cellular processes such as apoptosis, contraction, migration, and proliferation in many cell types. Here, TRPV4 is linked to posterior cortical atrophy.