The results of our pilot exploratory study show, for the first time, that plasma LRG1 concentrations were positively associated with circulating levels of previously identified high-risk plasma ceramide species [especially higher plasma Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0) and Cer(d18:1/24:1)] in postmenopausal women with metabolically well-controlled T2DM. The gene discussed is LRG1; the disease is type 2 diabetes mellitus.