In a cardiac hypertension model, GRP78 protein expression was increased in cardiomyocytes after high blood pressure was induced in mice, and exogenous overexpression of GRP78 in cardiomyocytes enhanced hypertrophic growth of cardiomyocytes via the activation of GATA-Binding Protein 4, intensifying the level of cardiac vessel hypertension [93]. Here, HSPA5 is linked to hypertensive disorder.