Furthermore, Bischoff et al., showed that hMLH1 promoter methylation was detected in 24 out of 64 (37.5%) primary EC and in 1 out of 18 (5.6%) metastatic tissues [98], confirming the opinion that hMLH1 promoter hypermethylation occurs in early endometrial carcinoma. The gene discussed is MLH1; the disease is endometrial carcinoma.