Its downregulation in HCC cells was linked to tumor development via targeting of crucial oncogenes such as cyclin G1 [45], ADAM10, IGF-1 receptor, ADAM17, CUTL1, Pkm2, Wnt1, pituitary-tumor-transforming gene 1 binding factor, Cut-like homeobox 1, c-myc, bcl-w, wnt-1, and others, as reviewed by Nakao et al. [88]. This evidence concerns the gene CUX1 and neoplasm.