Remarkably, TLR4 is expressed in HCC cells, Kupffer cells, activated stellate cells, and actively participates in multiple pathways involved in the innate immune response as described by Shi L. et al. [89], who also showed that miR-122 mimics strongly reduce TLR4 downstream cytokines, IL-6 and TNF-α. This evidence concerns the gene TLR4 and hepatocellular carcinoma.