SIRT1 and early-onset autosomal dominant Alzheimer disease: PARP1-mediated cell death is a common feature of neurodegenerative diseases, including Alzheimer’s disease [111], and since both PARP1 and SIRT1 activity depend on the availability of NAD+ [112], the increase in SIRT1 levels induced by oleuropein aglycone likely contributes, at least in part, to counteract PARP1-induced cell death.