This protective effect was later attributed to the ability of geniposide to block oxidative stress, inflammation, and associated pyroptosis by increasing total protein and phosphorylation levels of AMPK and SIRT1 protein levels and blocking NF-κB and NLRP3 inflammasome activation in both HFD/STZ-induced diabetic nephropathy in mice and HG-induced podocyte injury models [97]. The gene discussed is NLRP3; the disease is diabetic kidney disease.