SIRT1 and diabetic kidney disease: As geniposide, genipin-1-β-D-gentiobioside increased AMPK protein and phosphorylation levels as well as SIRT1 protein levels, thus blocking NF-κB and NLRP3 inflammasome in both HFD/STZ-induced diabetic nephropathy in mice and HG-induced podocyte injury models [99], suggesting that the mechanism underlying these effects of genipin-1-β-D-gentiobioside is identical to that suggested for geniposide.