Several studies suggested that eHsp90α is secreted via exosomes, based on the observation that DMA (Dimethyl amiloride), an inhibitor of the exosome secretion pathway, blocks Hsp90α secretion both in HIF-1-overexpressing tumour cells and TGFα-stimulated human keratinocytes cells, where Hsp90α was associated with isolated exosome fractions. The gene discussed is HIF1A; the disease is neoplasm.