CSN5. CSN5 has been found to be overexpressed in a variety of cancers, including breast, thyroid, skin, ovarian, lung, and liver cancers [188], while the knockdown of CSN5 by siRNA has been shown to inhibit cell cycle progression and cause strong induction of apoptosis in hepatocellular carcinoma cells [189]. Here, COPS5 is linked to hepatocellular carcinoma.