PSMD14 and Miyoshi myopathy: In another case of a known zinc chelator, O-phenanthroline (OPA) (EC50 = 10 μM) was also shown to induce apoptosis in MM cells and overcome resistance to the inhibitor bortezomib, which was ascribed to selectively inhibit Rpn11 activity without affecting other DUBs (e.g., USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37) [173].