In addition, differences in DAO genotype have been associated with alterations in the functional connectivity of the left precuneus and right posterior cingulate gyrus, both comprised in the default mode network, in patients affected by schizophrenia but not with bipolar disorder nor in healthy controls, suggesting that DAO dysfunctions may be detrimental when acting in a complex set of multiple neurobiological defects [298]. This evidence concerns the gene DAO and schizophrenia.