Thus, efforts are being made in Micheau’s team to understand more precisely how and under which circumstances DR4 and DR5 agonist receptors (1) induce a pro-motile/metastatic signaling pathway in tumor cells, (2) trigger apoptosis from within the cell, in a ligand-independent manner [136] and (3) require glycosylation to efficiently signal apoptosis upon engagement of TRAIL- or FasL/CD95-induced [136]. The gene discussed is TNFRSF10A; the disease is neoplasm.