Induction of ICD is emerging as a potent trigger of anti-tumor immune responses and can be induced not only by the activation of pyroptosis executioners like gasdermin D (GSDMD) or gasdermin E (GSDME), but also by the activation of Mixed Lineage Kinase Domain-like Protein (MLKL), which can similarly oligomerize and also directly disrupts the membrane integrity to cause necroptosis [22,23,24,25]. The gene discussed is MLKL; the disease is neoplasm.