TP53 and cancer: In addition, zinc participates in DNA transcription and replication through zinc finger protein and the p53 tumor suppressor protein, and so on, and zinc deficiency can affect the active DNA-binding expression of numerous transcription factors that are involved in cancer promotion and progression, such as AP-1, NF-κB, and p53 [118,121], which can lead to increased DNA damage, mutation, genomic instability, and increased inflammatory levels in the body, resulting in an increased risk of cancer.