In addition, zinc participates in DNA transcription and replication through zinc finger protein and the p53 tumor suppressor protein, and so on, and zinc deficiency can affect the active DNA-binding expression of numerous transcription factors that are involved in cancer promotion and progression, such as AP-1, NF-κB, and p53 [118,121], which can lead to increased DNA damage, mutation, genomic instability, and increased inflammatory levels in the body, resulting in an increased risk of cancer. Here, TP53 is linked to Zinc deficiency.