The transfection of cancer cells with pcDNA3-MnSOD significantly enhanced the expression of MnSOD, fibronectin, vimentin, MMP-9, and N-cadherin, and decreased the levels of E-cadherin in colon cancer cells above the basal level, indicating the mesenchymal-phenotype of these cells is promoted by when MnSOD levels go high in the cell. This evidence concerns the gene CDH2 and malignant colon neoplasm.