It was observed that TGFβ stimulation increased the levels of MnSOD, fibronectin, vimentin, MMP-9, and N-cadherin and decreased the levels of occludin and E-cadherin in colon cancer cells above the basal level, indicating the mesenchymal-phenotype of these cells is promoted by TGFβ. This evidence concerns the gene SOD2 and colonic neoplasm.