TRAP1 and neoplasm: While data supporting the importance of TRAP1 are numerous [24,47,48,49,50,51,52,53,54,55,56,57,59,60], these findings are challenged by other reports where TRAP1 expression inversely correlates with tumor stage [19] or is seemingly unimpactful in carcinogenesis models in TRAP1 knockout (KO) mice [61].