TYW3 and Parkinson disease: Validation of CA7 (logFC: 4.112885) mRNA levels (Figure 2A) confirmed that this intracellular carbonic anhydrase previously described to regulate neuronal pH buffering and actin dynamics [27] is highly upregulated in PD NPCs while CRYZ (logFC: −6.46325) and TYW3 (logFC: −8.48497), a quinone oxidoreductase, and an enzyme of wybutosine-tRNA(Phe) biosynthesis respectively [28], were almost absent in PD NPCs (Figure 2A).