The decreased expression of GRID1 (logFC: −1.36147), a glutamate ionotropic receptor subunit gene, and concurrent increase of GABRQ (logFC: 1.897966), a gamma-aminobutyric acid type A receptor, and SYT7 (logFC: 1.51335) encoding for synaptotagmin 7, that was recently shown to ensure high-frequency transmission at central GABAergic synapses [44], were confirmed in biological replicate samples (Figure 3D) and could be indicative of the neurotransmission imbalance in PD neurons. Here, GRID1 is linked to Parkinson disease.