There is also evidence showing elevated levels of proinflammatory adipokines (leptin) and decreased anti-inflammatory adipokines (adiponectin) in the GCF of obese patients with/without periodontitis, a direct reflection of the systemic changes of proinflammatory cytokine concentration in obesity [115]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.