The FTO of 410.5 kb locates on chromosome 16q12.2, encoding 2-oxoglutarate (2-OG) iron (II)-dependent alpha-ketoglutarate-dependent hydroxylase family dioxygenase [96] with well-described variants linked to obesity and an increased risk of osteoporosis [97]. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.