To investigate whether the injection of nondiabetic plasma-treated SVFs attenuates insulin resistance in diabetic mice, Leprdb/db mice were injected with Lepr+/+ plasma- or Leprdb/db plasma-treated SVFs followed by insulin administration, and the Akt phosphorylation in the liver of Leprdb/db mice was then measured. The gene discussed is INS; the disease is Insulin resistance.