Through a multivariate statistical analysis, the present work allowed to formulate hypotheses regarding the various risk factors associated with this non-compliance: Penicillin IgE-mediated allergy, certain types of surgery (colorectal surgery, hip prosthesis surgery, transurethral resection of the prostate) and two anesthesiologists who were frequently associated with transurethral resections of the prostate. This evidence concerns the gene IGHE and Allergy.