RYR2 and colorectal carcinoma: To identify the somatic mutations among the 537 CRC patients in the TCGA database, mutation data were downloaded, and a summary of the mutation information was visualized in Fig. 4A and B. The top 10 mutated genes in CRC by percentage are visualized, including APC (79%), TP53 (61%), TTN (47%), MUC16 (25%), SYNE1 (28%), KRAS (42%), FAT (22%), RYR2 (19%), OBSCN (18%), and PI3KCA (25%).