Moreover, spontaneously senescent pEOCs appeared to be able to reprogram the secretory capacity of normal peritoneal cells, e.g. by up-regulating the release by PMCs of PDGF-D that modulates extracellular matrix remodeling and stimulates ovarian cancer cell invasion [27] or by PFBs of NRP-1 and CXCL12/SDF-1 fueling ovarian cancer motility and metastatic potential [28, 29]. This evidence concerns the gene PDGFD and ovarian cancer.