STAT3 and ovarian cancer: Our data support the findings of studies that have identified several notable genes that are significantly differentially expressed in non-BRCA1/2 compared to BRCA1/2 HGSOCs including: EIF3CL which regulates a cluster of metastasis-promoting genes via STAT3 and acts as a mediator of immune cell evasion [71] and CFTR overexpression (also reported by TCGA) which is known to increase cell invasion, proliferation and adhesion in ovarian cancers [72], and is highly expressed in the fallopian tube secretory epithelial cells from which many HGSOCs arise [73].