We found significantly more DMRs (> 10% change, Q < 0.1) in primary versus recurrent tumors from BRCA1/2 non-carriers (11,205 DMRs in 16 tumor pairs, average of 659 DMRs per case comparison) compared to tumors from BRCA1/2 carriers (3,877 significant DMRs in 11 tumor pairs, average of 388 DMRs per case comparison) (P-value = 0.004). The gene discussed is BRCA1; the disease is neoplasm.