SLC12A5 and infection: Whereas, Corradini et al. reported that maternal infection with polyinosinic-polycytidylic acid (PolyI:C) causes downregulation of KCC2 transcription in the cortex of offspring mice, thus leading to delayed excitatory-to-inhibitory GABAergic shift and higher susceptibility to seizures in vivo, which endures up to adulthood [27].