However, the CpG island methylation located at the promoter region of BP1 (CpG island 1 in Fig. 1b) was undetectable in CML patients and K562 cell line by RT-qMSP, demonstrating that the CpG island located at the promoter region of BP1 was almost unmethylated in CML patients and K562 cell line. Here, DLX4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.