Hence, in our study, we verified that IL20RB was overexpressed in both ccRCC tissues and cells, and the ability of proliferation of ccRCC cells was inhibited after knockdown of the expression of IL20RB. Moreover, we conducted GSEA to identify possible pathways associated with IL20RB in ccRCC, and the results revealed that IL20RB might be involved in CCRI and IIN concerning IgA production and the p53 signaling pathway. This evidence concerns the gene TP53 and nonpapillary renal cell carcinoma.