High IL20RB expression levels were mainly enriched in cytokine-cytokine receptor interaction (CCRI), p53 signaling pathway, intestinal immune network (IIN) concerning IgA production, homologous recombination, hematopoietic cell lineage, arachidonic acid metabolism, primary immunodeficiency, glycosphingolipid biosynthesis of LACTO, and NEOLACTO series. The gene discussed is TP53; the disease is inborn error of immunity.