Consistently with our previous report on the oncogenic role of calcium in GC development [11], here we further reveal that CaCl2 and Hp virulence factors enhance the expression, activity and coupling of NCX1 and TRPC1 to promote GC development, strongly suggesting a critical role of TRPC1/NCX1-mediated aberrant Ca2+ signaling in Hp-associated GC. The gene discussed is TRPC1; the disease is gastric cancer.