Our results indicate the TRPC1/NCX1-mediated Ca2+ signaling increases AKT and β-catenin phosphorylation in GC cells, which supports our notion that TRPC1/NCX1 coupling induces GC development through the Ca2+/AKT/β-catenin pathway (Fig. 8N), further confirming the pivotal role of this pathway in GC as in our previous report [11]. Here, TRPC1 is linked to gastric cancer.