Given that DJ-1 has been previously reported to regulate the mitochondrial ATP-synthase activity32, and that ECs extracellular ATP generation increases after a period of incubation under ischemia-like conditions22, we sought to analyse whether ECs DJ-1/DJ-1∆C secretion under ischemia has an impact on the ecATP-S activity. The gene discussed is PARK7; the disease is ischemia.