TF and hepatocellular carcinoma: In poorly differentiated SNU-387 cells, conditions with increasing concentrations of TiO2-Tf-TC showed significantly greater hydroxyl radical generation in the presence of Y-90 microspheres compared to that without TiO2-Tf-TC, and was linearly related with Y-90 activity (Fig. 4A, increase of 88,426 HPF a.u. per Y-90 MBq/0.2 mL, 95% CI 83,815–93,037 for TiO2-Tf-TC 10 μg/mL, and increase of 111,557 HPF a.u. per Y-90 MBq/0.2 mL, 95% CI 105,464–117,650 for TiO2-Tf-TC 50 μg/mL, both r2 = 0.99, p < 0.0001), indicating that TiO2-Tf-TC enhanced oxidative stress in HCC cells in vitro.