Using a dual nano-photosensitizer consisting of titanium dioxide (TiO2) and titanocene (TC) labelled with transferrin (Tf) to facilitate tumor cell uptake (TiO2-Tf-TC), we show Y-90 microsphere treatment activated cellular and mitochondrial oxidative stress to enhance cell death in highly malignant and poorly differentiated SNU-387 HCC cells29. Here, TF is linked to hepatocellular carcinoma.