To assess if SOD1, HO-1, PRDX5, and GPX4 was also associated with and elevated in MS lesions, we performed spatial RNA sequencing analysis, as shown in Fig. 1C, on post-mortem non-neurological disease controls and MS brain tissue sections containing NAWM, an inactive core of a lesion, and its chronic active rim (Fig. 5A). This evidence concerns the gene HMOX1 and nervous system disorder.